Corticosteroids and Duchenne muscular dystrophy: does earlier treatment really matter?
نویسندگان
چکیده
Department of Physical Medicine and Rehabilitation, and Pediatrics, University of California, Davis, School of Medicine, Sacramento, California 95817, USA Department of Physical Medicine and Rehabilitation, University of California, Davis, School of Medicine, Sacramento, California 95817, USA Department of Pediatrics, Division of Pediatric Neurology, Alberta Children’s Hospital and Research Institute, Calgary, Alberta, T3B 6A8, Canada Department of Clinical Neurosciences, Division of Physical Medicine and Rehabilitation; Providence Medical Group, Olympia, Washington, 98195, USA
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Duchenne muscular dystrophy (BMD) is an inherited X-link disease. The incidence of this muscle-wasting disease is 1:5000 male live births. Mutation in the gene coding for dystrophin is the main cause of BMD. Most cases of this disease succumb to respiratory and cardiac failure in 3rd to 4th decades. The slow progression of BMD and recent achievement of gene therapies make it as an appropriate c...
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Duchenne muscular dystrophy is a relentlessly progressive X-linked disease. If untreated, boys develop symptoms of weakness before age 5 years, become wheelchair dependent by age 8–10 years, and develop respiratory muscle failure by age 14–18 years. Corticosteroids are of major benefi t because they improve muscle strength, increase muscle mass, and slow the progression of the disease for 18 mo...
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ورودعنوان ژورنال:
- Muscle & nerve
دوره 45 6 شماره
صفحات -
تاریخ انتشار 2012